15th Apr 2019
Introduction: The Saskatchewan Pediatric Bone Mineral Accrual Study (PBMAS) was initiated in 1991, when 248 boys and girls, aged 8-15 years, were recruited. Using serial measures (1991-1997, 2002-2007, 2009-2011 and 2016-2017) the study aimed to identify the development of body composition and its relationship to risk of adult disease. Previously, a relationship between adolescent trunk fat mass (TFM) and cardiometabolic risk at 26 years was identified. The present study examines developmental trajectories of TFM, during both adolescence and emerging adulthood (EA), of individuals categorized as either low or high metabolic risk (MRS) at 36 years of age. Methods: Fifty-five individuals were assessed from adolescence (11.5 ± 1.8 years), through EA (26.2 ± 2.2) into young adulthood (35.6 ± 2.2 years) (median of 11 visits) for anthropometrics, blood pressure, blood metabolites, DXA, diet and physical activity. MRS groups were created using sex-specific median splits of continuous standardized risk scores (blood pressure and serum markers) at 36 years of age. TFM trajectories were analyzed using multilevel random effects models. Results: The high MRS group had significantly steeper trajectories of TFM development in both adolescence and EA, 0.65±0.11 and 0.44±0.11 log g (p0.05) to TFM accrual, however physical activity was (−0.04±0.02; p<0.05). Conclusions: Young adults with high cardiometabolic risk at 36 years of age had greater trunk fat mass accrual during both adolescence and emerging adulthood. These results support the need for intervention at both these critical periods of fat accrual.